The Buddha describes these four inversions of perception, thought, and view, and the four non-inversions. An uninstructed ordinary person perceives permanence in the impermanent, pleasure in the unsatisfactory, a self in what is impersonal, and beauty in the unattractive.

In response to a king’s grief over his queen's death, the Buddha teaches that aging, illness, death, and loss are inevitable. He contrasts the self-torment of an ordinary person who resists these truths with the peace a learned disciple of the Noble Ones finds through acceptance, thereby removing the “poisonous dart of sorrow.”

The Dhamma can be like a snake that bites if grasped wrongly. This discourse tackles the danger of misinterpretation, sparked by a bhikkhu who claimed sensual pleasures weren't obstructions. The Buddha warns that a “wrong grasp” of the teachings leads to harm, while the right grasp leads to liberation. The ultimate goal is to use the teachings like a raft to cross over, letting go of all views—especially the view of a permanent self—to end suffering.

The Buddha provides a detailed analysis of the six sense bases, differentiating worldly feelings based on attachment from those born of renunciation and insight. He outlines a progressive path of abandoning lower states for higher ones, guiding practitioners through refined meditative states toward complete liberation.

The Buddha describes how to see the three felt experiences that are experienced on contact through the sense doors - pleasant, painful, and neither-painful-nor-pleasant.

The Buddha uses a simile of a bronze cup of beverage mixed with poison to illustrate how craving for agreeable and pleasant sense experiences leads to acquisition and suffering, while wisely seeing their impermanent nature leads to the end of suffering through the abandoning of craving.

Only after fully understanding the gratification, drawback, and escape in the case of form, felt experience, perception, intentional constructs, and consciousness, the Buddha declared that he had attained the unsurpassed perfect awakening.

The Buddha explains that those recollecting past lives are merely recalling one or more of the five aggregates. He defines each aggregate and shows how a noble disciple sees them as impermanent, dissatisfactory, and not suitable to identify with, leading to disenchantment, dispassion, and liberation.

The Buddha visits the dying lay disciple Dīghāvu and guides him to reflect on his solid foundation of faith and virtue (stream-entry), and then on deeper insights into impermanence. After his death, the Buddha declares him a wise non-returner, now bound for final Nibbāna.

Before his awakening, the Bodhisatta reflected on the gratification in the world, the drawback in the world, and the escape from it.

The Buddha shares the four kinds of persons — those who cultivate loving-kindness, compassion, appreciative joy, and equanimity while perceiving drawbacks — and the difference in their rebirths.

When approached with abundant offerings, the Buddha expresses a heartfelt wish to avoid fame, and speaks of five contemplations which result in being established in dispassion and wisdom.

The Buddha explains the distinction between how an uninstructed ordinary person and a learned disciple of the Noble Ones respond to the five unobtainable states of aging, illness, death, perishing, and loss.

Seven perceptions, of 1) unattractiveness, 2) death, 3) unpleasantness of food, 4) non-delight in the whole world, 5) impermanence, 6) unsatisfactoriness in impermanence, and 7) not-self in unsatisfactoriness, that when cultivated and frequently practiced lead to the deathless, in brief.

Seven perceptions, of 1) unattractiveness, 2) death, 3) unpleasantness of food, 4) non-delight in the whole world, 5) impermanence, 6) unsatisfactoriness in impermanence, and 7) not-self in unsatisfactoriness, that when cultivated and frequently practiced lead to the deathless, in detail.

After his full awakening, the Buddha surveys the world, seeing beings aflame with passion, aversion, and delusion. He reflects on the nature of the world and the suffering inherent in existence. By seeing the world as it truly is, he points to the path of liberation.